Watch Natalie Portman in Ominous New 'Annihilation' Trailer

A biologist portrayed by Natalie Portman finds herself entering an ominous world in the new trailer for Annihilation, one that makes her husband (played by Oscar Isaac) seriously ill and possibly makes people go crazy!

Based on Jeff VanderMeer's novel, the first book from his Southern Reach trilogy, Annihilation also stars Jennifer Jason Leigh, Gina Rodriguez, Tessa Thompson and Tuva Novotny.

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