Callies can be seen in Stewart Hendler's thriller, Whisper. The film is about a young boy who is kidnapped in a small New England town. Callies stars as the lead opposite Josh Holloway and Dulé Hill.

Callies starred in the film adaptation of James Redfield's international best selling novel The Celestine Prophecy. The film traces the efforts of a man attempting to track down an ancient Peruvian manuscript containing nine insights that supposedly prophesy the emergence of modern spirituality.

Additional television credits include the role of Officer Jane Porter on Tarzan as well as a recurring role on Queens Supreme with Oliver Platt. Callies has also appeared on Law & Order: SVU, Numb3rs and Dragnet.

Callies earned a Masters of Fine Arts degree from the National Theatre Conservatory.