Miller began his career in the industry on the other side of the camera. After graduating from college with a degree in English literature, Miller headed to Los Angeles in the spring of 1995 to work in the development department of a small production company specializing in movies made for television. However, it wasn't long before Miller's desire to realize the acting ambitions of his childhood became undeniable.

Within the next few years, Miller landed guest spots on a variety of shows, including Buffy the Vampire Slayer, ER and Popular. Miller also starred on the Hallmark "mega-series" Dinotopia.

Miller then segued to The Human Stain, a feature film directed by Robert Benton and starring Sir Anthony Hopkins and Nicole Kidman. A movie examining questions of race, class and identity, it features Hopkins as an embattled college professor struggling to conceal an incredible secret, with Miller playing the professor as a young man.

Miller subsequently appeared in the movie Underworld and guest-starred on Joan of Arcadia and Ghost Whisperer before joining the cast of Prison Break, for which he was nominated for a 2006 Golden Globe® Award for Best Performance by an Actor in a Television Series - Drama.