He co-stars opposite Hugh Jackman and Rachel Weisz in director Darren Aronofsky's The Fountain. He also stars opposite Seann William Scott, Billy Bob Thornton and Susan Sarandon in New Line Cinema's comedy, Mr. Woodcock.

Suplee made his feature film debut in 1995, alongside his My Name Is Earl co-star Jason Lee, in writer-director Kevin Smith's Mallrats, where he played the memorable "William Black," a young man determined to crack the mystery behind the mall's magic eye poster. Smith went on to cast Suplee in Chasing Amy and as the voice of "Norman the Golgothan" in Dogma. He makes a cameo appearance in the director's feature Clerks II.

Suplee's additional credits include director Terry Zwigoff's Art School Confidential, Without a Paddle with Matthew Lillard and Seth Green; director Anthony Minghella's Cold Mountain with Jude Law and Nicole Kidman; Blow with Johnny Depp; director Todd Phillip's Roadtrip; Evolution for director Ivan Reitman; and director Tony Kaye's American History X with Edward Norton and Edward Furlong.

Ethan Suplee can be seen in the telefilm The Year Without a Santa Claus, with John Goodman and Chris Kattan. He plays the role of "Jingle," one of Santa's right-hand elves, in this live-action remake of the animated classic.

Born in New York and raised in Los Angeles, Suplee landed his first role at 16 on the popular television series Boy Meets World, where he recurred as the reluctant bully "Frankie" for three seasons.