Chyler Leigh , born in Charlotte, North Carolina and raised in Virginia Beach and Miami Beach, began her career in front of the camera at age twelve, modeling for magazines and catalogues. Her success in print later led to national commercials for Coca Cola and Wendy's, among others.

Ellen Pompeo made her major studio screen debut in Brad Silberling's "Moonlight Mile," starring alongside Susan Sarandon, Dustin Hoffman and Jake Gyllenhaal. She received outstanding reviews for her portrayal of an outspoken young woman carrying a silent burden that's breaking her heart.

Patrick Dempsey is perhaps best known as the unlikely heartthrob of such classic 80s nostalgia films as "Can't Buy Me Love" and "Loverboy", and has since grown in to a mature actor and a talent that Hollywood continues to recognise. He recently completed production on Paramount's "Freedom Writers," opposite Hilary Swank, and the Disney film "Enchanted."

Katherine Heigl was born in Washington, DC, but raised in New Canaan, Connecticut. Heigl began her career at the age of nine as a child model. It wasn't long before she graduated to commercial work, which opened the door to auditions for film roles. By age 12 she made her feature debut in "That Night," starring Juliette Lewis and C. Thomas Howell.

James Pickens Jr., is well known to viewers for his recurring roles on numerous television series, including "The X-Files," "NYPD Blue," "Philly," "The Practice" and "Six Feet Under." Most recently he starred opposite Rob Lowe in the ensemble drama "The Lyon's Den."

Sandra Oh was born and raised in Ottawa, Canada, where she started ballet lessons at the age of four and performed in her first play, "The Canada Goose," at the age of ten. She started working professionally at age sixteen in television, theatre and commercials.

Sara Ramirez joined the cast as a regular in Season Three as orthopedic surgeon Dr Callie Torres. Prior to "Grey's Anatomy, Ramirez was seen in the Broadway smash-hit "Monty Python's Spamolot," as Lady of the Lake, for which she earned both a Tony Award for Best Performance by a Featured Actress in a Musical and an Outer Critics Award for Outstanding Featured Actress in a Musical.

Chandra Wilson is a 2006 Emmy Awards nominee for her audience-pleasing performance as Dr. Miranda Bailey on the drama series, "Grey's Anatomy." She was also nominated for an NAACP Image Award for the role, and was recently recognized in Entertainment Weekly's year-end issue as one of the year's "Great Performances, Memorable Moments from 2005."

T.R. Knight was last seen on Broadway as Damis in "Tartuffe," with Brian Bedford, and as Tim Allgood in Michael Frayn's "Noises Off," opposite Patti LuPone, Pete Gallagher and Richard Easton.

Justin Chambers was born and raised in Springfield, Ohio. Discovered on a subway in Paris, he began his career as a professional model working throughout Europe, Japan and the U.S. with contracts at Calvin Klein and Armani, among others.

Eric Dane first appeared on "Grey's Anatomy" in 2006 as Dr Mark "McSteamy" Sloan. Since then television viewers everywhere have shown much interest in this scene-stealing actor. Dane's career is rising fast, recently appearing on the cover of USA Today and TV Guide, proving his staying power.