Most Grey's Anatomy die-hards love Izzie Stevens and George O'Malley together. "I LOVE them together and have wanted them as a couple since I started watching the show because they have such a close bond, they can't stand not having each other around, and I think they're cute together," was one viewers comments.

And then there are those, a small percentage but we'll find out how many on our poll this week, so passionately against the match they are screaming out for them to break up before they've barely even begun. "Oh please...George and Izzie? You couldn't get a couple more badly matched than George and Izzie. They don't even look good together," was one anti george-Izzie remark.

George and Izzie have been given the Grey's Anatomy-style nickname 'Gizzie', which is cute, kind of, but it also sounds a little bit like a sex toy, kind of apt really given their ill-matched libidos. They might need one of these Gizzies to keep their sexual appetites flowing over the course of their relationship, how ever long it may last. They've consummated their relationship, once when they were both so drunk they can't even remember it. And now they are together they can't actually get it together! So what's going on with them?

They seemed well-matched at the start, always confiding in each other, acting like best friends do. But the question is do they really have the big C connection going for them, CHEMISTRY? Maybe they are just trying way too hard. Well Izzie definitely is, she's trying so hard she's turned in to a bit of a crazed lunatic. Keep it together girlfriend or you'll lose your man completely. The golden rule is never to push something or you'll push it in the opposite direction. Our advice to Izzie is just be light and breezy, seriously! Otherwise George just might run back in to the arms of Callie, creating a Gallie situation.

Have your say, what do you think of the George-Izzie Gizzie thing? Do you think they have chemistry but it's been a bit blurred by Izzie's over-zealous behaviour? Or do you think their chemistry is just the best friend kind and the relationship boundaries have been skewed? If the latter is the case there may be some rocky times ahead for our Gizzie couple.

Well the juries out, George and Izzie are "Hot to Trot", as voted by you. Only 15% said they had zero chemistry while 63% said they ooze the stuff.