Last week, we were left with two very big questions, and one is answered right away when George and Callie come back from Vegas as George and Callie O'Malley. That's right, it really does sound that funny, which Alex points out. The Denny Duquette Memorial Clinic is now open for business, but as they only dreamed the thing up eight days previously, it's not yet bustling with patients. Izzie can only think about the money being wasted and eventually has herself excused, but Bailey sticks around to help their one patient, and is able to make a difference in the girl's life, which makes the whole endeavour worth the effort. Though that's the only actual clinic patient, some of the other beds are used by George and some other members of the staff. George realises they're all sick because one of their patients' blood is toxic, but before he can warn her surgical team, they've all passed out in the OR after cutting her open. Eventually she's patched together enough to get her out of the OR before she comes out of anesthesia for a second time, which is finally accomplished by some daring breath-holding and dashing surgery by the female interns.

This week's heart-wrenching comes courtesy of Meredith's mother. She wakes up lucid, which is a not unheard-of but temporary condition for an Alzheimer's patient. Meredith has to break it to her that she has the disease, and the stress causes her to collapse. She's taken to Seattle Grace, where it's discovered that she has heart disease and needs surgery. Cristina takes care of her and befriends her, since the elder Dr. Grey sees a kindred spirit in the intern. Unfortunately she doesn't see that in Meredith, and when she finds out Meredith is happy and in love, she lays into her for being a giant disappointment.

It's no wonder Meredith had been avoiding having a real conversation with her mother, however little time they might have together. When Meredith finally ventures back into her room at the end of the day she emotionally and honestly tells her mother she hopes they can get to know each other one day, only to find out that she's slipped back into her mental prison.

Cristina realises through the day's events that she wants to be a surgeon AND have a life, and she finally gives Burke an answer, which is yes.

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