First of all, Meredith snores so loud that Derek apparently never actually spends an entire night in her bed, but sneaks off to get sleep elsewhere and sneaks back in before she wakes up. While dealing with this new knowledge about herself, she's also dealing with running into her father repeatedly; he's hanging around the hospital looking after his new granddaughter whose mother and grandma are conveniently gone with the flu. They share a couple of awkward meetings with one another but she still can't forgive him. When the baby is rushed to surgery, she can't bring herself to help comfort him or give him updates, though Richard tries to tell her to ask him what really happened when he left and why he didn't ever get in touch with his firstborn daughter. The baby's surgery isn't alienating everybody though, as afterward Alex and Addison almost share a kiss after he admits that he's not going to pursue plastics with extra-grumpy McSteamy.

George's dad has his cancer surgery and, unbeknownst to George, has told Bailey and Richard that he wants them to take out the tumor no matter how badly it has spread. When they open him up, it looks like he could have a tough recovery ahead of him. But so far his kidneys are working, which is a sign so good that it makes George dance and kiss Callie in front of his mum and brothers. They're much more functional than Cristina and Burke, who are together but each refusing to be the first one to speak to the other, and by the end of the hour, neither one has broken down.

A patient is in the hospital with a rare condition that has left her spine severely bent and she has to live life at a 90-degree angle. Callie convinces Derek to see her, and he says he can do experimental surgery that might actually help straighten her out. Izzie wants to be in on the surgery but Bailey won't let her until she gets the all clear from psych... which psych is not doing until Izzie deposits The Cheque. She finally realises that surgery is more important to her, and takes her crying self down to the bank to leave the eight million dollars somewhere safe and interest-bearing. Unfortunately, she's not going to be in on the surgery in the end anyway, since the girl's insurance company has turned it down and her mother can't afford to pay for it.

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