It's hard to resist a couple on the run, as the results of this poll show, with Prison Break's Sara and Michael winners by a mile. It also helps that Wentworth Miller is the hunkiest leading man on our screens. But as diehard fans will know, by the season finale, viewers were left devastated by Sara's fate - the end of TV's favourite couple?

Competition for second place was between tumultuous hospital lovebirds Meredith and McDreamy, and Home and Away's Jack and Martha. With Jack now married to Sam and the Grey's lovebirds under a dark cloud in the season finale, this poll may have to re-drafted in 2008...

Number of votes: 7894
Michael and Sara - Prison Break 41%
Jack and Martha - Home And Away 24%
McDreamy and Meredith - Grey's 20%
Betty and Henry - Ugly Betty 8%
Brian and Marjorie - What About Brian 7%