This couple have had more dramatic moments than most in this list. After a funny courtship involving pranks, spiders and misunderstandings, their wedding exploded in more ways then one.

Meredith's looks and quirky personality would get under most men's skin, and McDreamy is the hottest of hot blooded males. With McSteamy and Addison around to stuff things up, this relationship has been will they/won't they for months.

Since their Season One kiss this couple have had mountains to climb to be together. She allowed him to escape from prison, but the cost was the life of her father (and on numerous occasions very nearly her own). But this girl won't give up the fight...

Betty's butterfly costume is symbolic; it represents her blossoming from Queens girl to Manhattan-chic-about-town, and the realisation that her relationship with Walter is part of her old life.

Brian and Marjorie are the cross this show has to bear. Since their furtive kiss and a series of mishaps - including her walking out on Brian's best friend Adam at the altar - this couple seem destined to fail and take others with them.