Brothers and Sisters follows the Walkers through the maze of American life today - the pressures, limitless options and the struggle to grow beyond our backgrounds into ourselves. Through these fascinating siblings - Sarah (Rachel Griffiths), the corporate executive struggling to balance motherhood with career; Tommy (Balthazar Getty), the loyal son and seeming heir to the family business; Kevin (Matthew Rhys), the gay lawyer cautiously learning about love; Justin (Dave Annable), the baby of the family, grappling with war trauma and addiction; and Kitty (Calista Flockhart), right-wing radio host turned TV pundit who has always been Daddy's little girl.

The show explores what it means to be a family in the 21st century, and how these brothers and sisters balance their own lives as they strive to accept their parents as people - flawed, contradictory and forgivable - rather than just as a father and mother.

The parents are Tom Skerritt as William Walker, the larger-than-life patriarch and president of the family business (who dies mysteriously at a family birthday party in episode 2), and Sally Field as Nora Holden, the opinionated wife and mother to the five Walker siblings. Then there's Ron Rifkin as Saul Holden, Nora's brother and the company's second in command; John Pyper-Ferguson as Sarah's husband, Joe; Sarah Jane Morris as Tommy's wife, Julia; Rob Lowe as conservative Senator Robert McCallister (a romantic interest for Kitty) and Patricia Wettig as the mystery woman who could bring the Walkers and their company down.

Ken Olin (Alias, thirtysomething), Jon Robin Baitz (The Substance of Fire, The West Wing) and Greg Berlanti (Everwood) are executive producers.