It is the morning after the engagement and Dan, Erica and Jack are running late for work when they find a middle aged woman on the bonnet of Dan's car. After she is taken via Ambulance to All Saints, it is soon discovered that her incoherence and her physical frailty are the result of Huntington's disease, a cruel degenerative affliction. Margaret Coolage is in the final stage of the disease and she has been on the street for three days after slipping away from her primary carer - her daughter, Natasha. Working with Natasha to care for this seeming lost cause, Dan comes to realise that if he is going to have a bright future he needs to start taking more responsibility for his own health - today.

For Mike, this day could not come soon enough... His first day back in surgery after his kidney donation. However, he is soon put to the test when Tim Spillane is brought in after impaling himself on a fence post. Things begin to go from bad to worse, requiring a Herculean physical effort from Mike and by the end of the day he comes face-to-face with his own limitations... with a little help from Frank.

... Which may be the last help Frank gives anyone at All Saints as word of his resignation gets around the ED. But just how will his staff, in particular his 2IC, Zoe, react to the news?

Charlotte and Erica struggle to help Evan Fallon, a young man who refuses to be forthcoming about the nature of his problem. However, when Jack talks to Evan, the truth finally comes out. It seems that Evan had a bigger 21st birthday that he had been willing to admit and the outcome has seen him consumed by shame. Our team help Evan realise that at 21, it might be time for him to become a man.

Bart comes into the ED to announce that Ann-Maree died the night before and Von quickly recognises that he is sinking in grief. However, she may have something to help him navigate his way through.