Mike's offer to donate a kidney to his son is rejected.
Bart and Ann-Maree return from holidays to some devastating news.
A routine homecare visit turns into a trauma for Von.
Steve and Dan learn a lesson about the human side of medicine as they take care of a homeless man.
As Zoe contemplates her own future, a patient's lonely end reminds her that you sometimes have to look out for yourself.
CONTINUITY FROM PREVIOUS EPISODE:
Von, not coping at all in the aftermath of the siege, asked Frank for a prescription to help her sleep.
Frank was hauled back to Admin over his unauthorized statement to the media in Ep 417.
Elizabeth told Oliver she wasn't feeling at all comfortable about spying on Frank for proof that he was the Whistle Blower... but Oliver was clear that she wasn't backing out now.
Zoe pointed out to Frank that he has no allies in the hospital whatsoever.
Bart and Ann-Maree's holiday was cut short by the news that her very optimistic Pathology results may not have been correct.
Mike made the decision to donate a kidney to his son.

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And mike, i so dont want him to leave! I love him!