Frank and Dan treat a 15 year old girl, Georgina Feeney, suffering end stage heart failure. Her only chance of survival is a heart transplant. She has fluid in her lungs and it has to be drained. She dreads the procedure she's been through so many times before. Her father, Ethan, confesses to Frank that each day he prays for someone else to die so that she can live. When a donor heart suddenly becomes available the ED team has two hours to take bloods to check for a match and prepare her for transfer to the hospital where her new heart is waiting. The clock starts ticking.

Mike and Erica fight to save the life of a patient, Brian Hilton, badly injured in a construction site accident. Gabrielle discovers he has bought a wedding anniversary card and airline tickets for a second honeymoon. They fight to stabilise their patient and get him to Theatre. When they are ready to take him up they discover that the Lift isn't working. They have to return to Resus. The clock is ticking for their patient.

Bart has persuaded Ann-Maree to come in to All Saints to be examined. He believes they need to know what they are facing. Ann-Maree is scared of knowing. She refuses to see her Oncologist. Bart asks Jack to see her. When Jack examines her he finds a swollen lymph node in her armpit. Ann-Maree insists he tell her what he thinks is going on. Jack is forced to admit that her cancer may have spread. Ann-Maree can't cope. Jack is angry Bart didn't tell him he was in a relationship with Ann-Maree. Frank's angry too and tries to make Bart realize what he's doing. He's in a relationship with a vulnerable patient. A medical tribunal would see that as ethical misconduct. His career is on the line. But Bart tells Frank to back off, it is none of his business. We're left wondering if Ann-Maree's cancer has really spread, and if Frank is right that Bart is setting himself up for massive heartbreak.

Mike receives news that he is able to donate his kidney to his son. He is a match. But what will Mike do?

James, the new Maintenance man, brings in Melissa, who last came in to the ED as the result of a panic attack. He says he found her panicked in the Ambo Bay. She says she is suffering chest pains, but Zoe suspects she's only there to see Heath again. James starts to work on fixing the Lift.

Mike can't wait any longer. He decides he needs to take his patient to Theatre via an outside route. At the same time Frank learns that Georgina is a match for the donor heart and the team rush to transfer her. But they find that the Ambo Bay door won't open. What's going on?

James, Melissa and an accomplice, Smokey, hold up the ED at gunpoint. They want to clear out the drug room. The clock is ticking for the young heart patient, Mike's trauma victim and Ann-Maree and Bart. When James reveals that they will all be held here until he has gone to rob the Hospital Pharmacy Frank confronts him. How does he think he'll get away with that? It is then that James reveals he has something planned that is certain to keep everyone distracted.

Jack waits in the Pathology Lab for Ann-Maree's results. The clocks ticks.